Below is a list of supplements and their uses, common dosage recommendations, and brands that we use. I’ll be adding to it as I learn of new ones. These are all specific to biomed protocol for treating autism, but many of these are helpful for just about anyone. DMG and it’s use in the treatment of Autism Spectrum Disorders. DMG is Dimethylglycine (Pangamic Acid), it is an amino acid that is found in some foods naturally such as red meat, some grains and legumes.
Autism is a developmental disorder for which its etiology is not well understood. It has been described as being a complex behavioral and neurological disorder in which impaired communication and lack of social skills are the hallmarks of the condition.
The disorder has been possibly linked to genetic, neurological, gastrointestinal and immunological defects as well as to environmental toxins such as mercury and chlorinated hydrocarbons.
A 2018 study (1) demonstrated that children with Autism Spectrum Disorder (ASD) have increased inflammation and significant differences in their immune system and GI microbiota profiles as compared to the non ASD population. According to a recent study in The American Journal of Clinical Nutrition, impairment of methylation and detoxification pathways have also been a factor for many with ASD. https://kvdxrr.weebly.com/cc-cleaner-mac-download.html.
Autism is a growing problem for which no single treatment program has been found to be totally successful. Many people with ASD appear to have their own unique set of symptoms. The best approach to help remediate the condition seems to center on developing a personal comprehensive program based on multiple factors including dietary changes, nutritional supplements, detoxification, GI support and the use of behavior modification programs.
Recent studies have been shown that DMG may have beneficial effects on autistic individuals.
A longtime advocate for the use of DMG for those individuals on the autism spectrum disorder (ASD) has been Bernard Rimland, PhD, the founder and past president of the Autism Research Institute in San Diego. Although Dr. Rimland passed away in 2006, he’s keenly remembered for his dedicated life’s work to find the causes and solution to the autism puzzle.
Dr. Rimland was the first researcher to bring the attention to the autistic community as to the potential benefits of DMG in helping to improve and alleviate the symptoms and abnormalities associated with autism.
He discovered earlier findings by Russian investigators who reported speech improvement in speech handicapped children who were given a product containing DMG. Since 1980, he has recommended to parents with autistic children that they try DMG to see if the nutrient would help improve their child’s communication issues.(2)
The feedback from parents to Dr. Rimland’s Treatment Effectiveness Questionnaire over the next few years was excellent. Many parents and teachers reported significant improvement in a number of areas after starting to use DMG including:
- Improved speech communication
- Better social skills
- Better eye contact
- Improved quality of sleep
- Positive behavioral improvement
Over a period of time, Dr. Rimland collected over 6,000 survey reports in which 42% of the parents rated DMG as offering a beneficial result to their children. Based on the complexity of the disorder, this is a highly favorable report with only 8% reporting a less favorable result.
Dr. Rimland reported that if DMG is going to work, in most cases, parents should see a change within a week or two but advises parents should try it for at least a month before discontinuing use.
Two large studies have reported the benefits of DMG for autism.
Dr. Lee Dae Kun, Director of the Pusan (Korea) Research Center on Child Problems reported to Dr. Rimland that he observed an 80% improvement in a group of 39 autistic children, ages three to seven, who were given DMG over a three-month period.
He observed improved speech communication, dietary choices, cooperation, sleeping patterns and bathroom habits. The parents reported that they clearly saw improvement in their children. Dr. Kun concluded that DMG can be beneficial for children with autism, even if it is not a cure.
In a second study, Doctors Jung and Lee of the Springtide Foundation in Taipei, Taiwan published a double blind study of DMG in 84 autistic children in the Tzu Chi Medical Journal in 2000. The research showed short time and from mild to moderate effectiveness of the DMG with children with autism. The DMG group showed significant improvement in irritability, lethargy, hyperactivity and inappropriate speech.(3)
The reasons why DMG brings about improvement in autistic children is not clearly known but it may be due to DMG’s support of methylation, immune response, detoxification and gut health.
DMG can also make a positive contribution in many areas of cellular metabolism including neurotransmitter production, oxidative stress reduction and energy production in the brain. Perhaps future research in this very important field will shed more light on why DMG can benefit the lives of many children with autism.
The following is a small sample of the letters Dr. Rimland received over the years.
Dear Dr. Rimland,
In December of last year, my husband and I began our son on DMG. Matt was four years old and non- verbal for the most part. Two to three weeks later he began to babble, and then use jargon. After 2 months, he began to make many word attempts and by June was speaking words. Today he speaks well over 200 words and many are two word phrases.
When I tell people about DMG, they ask “do you think that DMG did all of this?” I reply that I think it really helped. It’s cheap, very easy to get and administer and is a nutrient that can’t hurt. It may not work with your child, but is worth trying.
A New York Mother
To the Editor,
Hurray for DMG! Our 14-year-old daughter, who has ADD and is hyperactive with strong autistic tendencies, recently started taking DMG and within two days we were noticing some major changes in her behavior. She had a greatly reduced frustration level and her teenage hostility and /or oppositional behavior has diminished considerably. Homework is now a pleasant experience and her organization skills have increased. The bottom line: she is a much happier person.
A California Mother
References:
(1) Rose, D. Et al., “Differential immune responses and microbiota profiles in children with autism spectrum disorder and co-morbid gastrointestinal symptoms,” Brain, Behavior and Immunity, 2018 (March)
(2) Rimland, B. “Dimethylglycine, a Nontoxic Metabolite, and Autism,” Research Review International. 4(#3), 1990
(3) Jung, S. and Lee, Y. “A Double-Blind Study of Dimethylglycine with Autism,” Tzu Chi Medical Journal, 2000; 12 pp 111-121
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Nutritional Therapies and Autism
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Nutritional Therapies and Autism
Vitamin B-12:
Vitamin B-12 shots have been used for autism, usually at a dose of 1000 micrograms (1 cc) intramuscularly per treatment. Amounts above 1000 micrograms may be excreted in urine since this is a water soluble vitamin. There are no reported cases of B-12 toxicity even at high doses.
B-12 is sometimes given several times for the first week, then weekly for about 3-6 weeks, then monthly for three months, and then put on maintenance therapy.
Screening tests for B-12 deficiency include serum and urine methylmalonic acid levels. It is not necessary to have low levels to benefit from B-12.
B-12 works better with folic acid, whose deficiency is common among people with bowel disorders and epilepsy. Folic acid deficiency is common in celiac disease.
B-12 does take some time to work initially, up to a few weeks. When improvement occurs, it typically does so about 2-4 weeks after the first injection and lasts 4 weeks. Some report that up to three months sometimes pass before improvements are seen with B-12.
For general information about Vitamin B-12 see:
- Wikipedia: Vitamin B-12
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Magnesium:
Intramuscular or intravenous magnesium is sometimes helpful, but may also produce increased agitation.[Return to 'Quick-Index' of Nutritional Therapies and Autism]
Gluten and casein free diets:
Urinary peptide tests are available to assess for this. The urine is tested for the presence of certain opioid compounds which are a by-product of incomplete digestion of the gluten and casein proteins. These compounds are thought to be hazardous to the brain, producing or magnifying the autistic symptoms. The labs who do these tests include:
Great Plains Laboratories: Gluten & Casein Urinary Peptide TestBest dmg. Sample Requirements: 5 ml first morning urine.
Panel Includes:
- Casomorphin peptide
- Gliadorphin peptide
Another source of peptide testing is:
Dr. Robert Cade
Depts. of Medicine & Physiology
University of Florida
Phone: 352/392-8952
FAX: 352-392-8481
Theoretically, if these peptides are present in the urine, eliminating gluten and casein from the diet will be helpful. https://kvdxrr.weebly.com/plex-download-mac.html.
In my experience (LMM), sometimes eliminating gluten and casein is helpful despite the absence of these metabolites. My suggestion to try the elimination for two months regardless of the test results when autism is present.
![Dmg Supplement Autism Dmg Supplement Autism](/uploads/1/3/4/3/134363936/732935716.jpg)
Gluten can reduce the secretion of the hormone, secretin, which has central nervous system effects.
- A Note About Including Oats in Gluten Free/Casein Free Diets:
Some literature shows that children on the gluten free/casein free diet can apparently eat oats, though many potential problems still exist with most oat preparations, since they may be grown in fields that rotate with wheat. Such crops of oats may inadvertently contain wheat.
It is possible that oats grown without rotation in fields of gluten-containing grains would produce no adverse effects on autoantibody or intraepithelial lymphocyte levels in gluten sensitive patients, however very few oat products are grown this way.
The GFCF Diet Support Group states: 'Less than 5% of the oats which are now grown commercially are for human consumption. The chief value of oats remains as a pasturage and hay crop, especially for horses. Oats are also used in crop rotation. The possibility of cross contamination is the issue here, rather than the glutenous type of protein which is not found in oats. However, oats are considered unacceptable by our standards.'
'Wheat, rye, and barley have harmful effects on the small intestinal mucosa of patients with celiac disease, whereas maize and rice are harmless,' wrote Dr. M. I. J. Uusitupa, from the University of Kuopio, and colleagues in the March 2000 issue of Gut.
His research team studied two groups of patients: 40 adults with newly diagnosed celiac disease and 52 adults whose celiac disease was in remission. Patients in both groups were randomized to a conventional gluten-free diet or a gluten-free diet containing oats, and were monitored for autoantibodies and intraepithelial lymphocytes over a 6- or 12-month period.
The rate of disappearance of antireticulin antibodies, antigliadin antibodies, and intraepithelial lymphocytes were similar, regardless of diet, among patients newly diagnosed with celiac disease. Similarly, antibody and intraepithelial lymphocytelevels were similar among patients whose celiac disease was in remission.
The authors wrote, 'These results strengthen the view that adult patients with celiac disease can consume moderate amounts of oats without adverse immunological effects.'However, in light of the fact that most available oat products are likely to be contaminated with other gluten grains, we urge that people err on the side of caution regarding including oats in a gluten-free diet, especially when there are better alternatives, such as rice products, available.
For more information on this topic, please see: the Gluten/Casein Theories of Autism and its Relation to Celiac Disease section on our Overview page.
For information about special diets see:
- The Gluten-Free Website Collection
- Wheat-free, Milk-free Diet for Autism and PDD
Another resource for cooking without dairy, sugar or wheat is the Natural Gourmet Cookery School, 48 West 21st Street, New York, NY.
[Return to 'Quick-Index' of Nutritional Therapies and Autism]
Pancreatic Enzymes:
Many anecdotal reports exist of the helpfulness of pancreatic enzymes for the digestive problems of autistic children. Nevertheless, other parents report that their children regressed on pancreatic enzymes (including the legendary Victoria Beck). I have seen both results in my experience, and have no way to determine which will happen. Needless to say, some children show no change. Cotazym and Creon are two of the most common pancreatic enzymes used.
Here is a typical story:
When my autistic daughter was born, she had severe diarrhea. After manytrips to the Pediatrician and changing her formula daily, it was decidedshe may have Cystic Fibroses. Thus she was given Cotazym. The firstday Maggie was on the meds, she slept all night (she was sleeping 10minutes at a time, 24 hours a day before) and the diarrhea stopped.
Upon starting pancreatic enzymes, some autistic children show improvements in speech, eye contact, tolerance, awareness of surroundings and self, improved color, and more understanding.
Cotazym, and other pancreatic enzymes, are given 4 times a day. Sometimes, one must open the capsule and mix the powder with something that does not need chewing (pudding, ice cream, jello). Unfortunately, then the powder starts breaking down the food before it is eaten.
Creon 10 is supposed to be delayed release. Creon 10 starts breaking down the food inthe intestines instead of 'on contact', which means it should not turn pudding into water before it can be eaten.
These medicines do not hurt the kids systems; anything they do not need they simply pass.
Pancrease capsules used daily have been anecdotally reported to solve problems with loose stools.
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Colloidal Silver:
Colloidal silver in a glass of water can also help with diarrhea, as well as frothy andsmelly stools. It is often given once a month.For more information about colloidal silver please see:
- What do We Know About Colloidal Silver?
[Return to 'Quick-Index' of Nutritional Therapies and Autism]
Super Nu Thera:
A product called Super Nu Thera powder has been reported anecdotally as helpful, but sometimes make children more irritable.
'A new, good-tasting vitamin B6 and magnesium formula, Super Nu Thera 500, is now available from the Kirkman Company of Wilsonville, OR. SNT-500 is a strawberry flavored liquid concentrate that is well-accepted by the vast majority of autistic children. The company will continue to sell the Super Nu Thera formula as a flavored power and as unflavored tablets. All three products contain, in addition to the B6 and magnesium, 20 other nutrients designed to enhance the effectiveness of the B6.To contact Kirkman:
- Phone: 1-800-245-8282
- Fax: 503- 682-0838
(Courtesy Autism Research Institute's Suggested Dosages for Nutritional Supplements)
https://kvdxrr.weebly.com/dmg-files-learner.html. [Return to 'Quick-Index' of Nutritional Therapies and Autism]
Omega-3 Fatty Acids:
A new Omega-3 supplement has been developed by European Reference Botanical Laboratories, Inc. (ERBL). The new product called Coromega comes in an easy-to-use foil packet which doesn't spoil and contains a daily dose of Omega-3.
While the best source of Omega-3 remains cod liver oil and fish oil, this supplement is readily absorbed in the bloodstream. Omega-3 supplements in the past have been known to taste bad. ERBL claims to have solved this problems and says the new product tastes like 'orange creamsicles'.
See Coremega: An Omega-3 Dietary supplement for more information.
Dmg Supplement Dosage For Autism
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Dimethylglycine (DMG):
'For over 20 years ARI [Autism Research Institute] has been hearing from parents who have tried DMG on their autistic children. In many cases remarkably good results have been seen, especially in enhancing speech. In some cases, drug-resistant seizures have been stopped by DMG. (See New England Journal of Medicine, 10-21-82, pgs 1081-82).
There is an extensive research literature on the safety and health benefits of DMG. Many studies have shown that DMG enhances the effectiveness of the immune system, improves the physical and athletic performance of humans and other animals (e.g. race horses) and has, all in all, a very wide range of beneficial effects. It is very safe. I have seen no evidence of any toxic or significant adverse effects. DMG is available in many health food stores in small, foil-sealed 125mg tablets from Food Science Laboratories. Ask for the original Aangamik DMG or for further information from the company, call toll-free at 800-992-8451. (Avoid DMG in liquid or large tablets.)
Dimethylglycine is technically classified as a food. It is found, in very small amounts, in some foods, such as brown rice and liver. Chemically and physiologically, it resembles the water-soluble vitamins, such as the B vitamins. The main reason it is not classified as a vitamin is that there are no specific symptoms associated with a deficiency of DMG.
Many parents have reported that, within a few days of starting DMG, the child's behavior improved noticeably, better eye contact was seen, frustration tolerance increased, the child's speech improved, or more interest and ability in speaking was observed.
For a pre-school child, I would start with 1/2 of a 125mg tablet or capsule a day, with breakfast, for a few days, or one tablet a day for a larger child. I would go up, gradually, to one to four tablets a day for a child, and to 2 to 8 tablets per day for an adult. If there is an initial increase in hyperactivity (rare) reduce the dosage. If the hyperactivity continues, the child may be telling you, in effect, that he or she needs more folic acid. Folic acid is a very safe B-vitamin. Purchase some 800mcg folic acid tablets and give two of these with each 125mg of DMG.
If you are just starting out, I suggest giving the DMG for 2-3 weeks then adding the B6/magnesium (which should also be started gradually: write to us for publication 39F). When you start a trial of DMG, don't confuse the results by simultaneously starting other vitamins, drugs, or other forms of treatment that might make it difficult to tease out the effects of DMG from the effects of the other things tried. If the child is already taking vitamin B6 and magnesium, or anything else that is helpful, there is no reason to stop taking the B6 (or whatever). The DMG is merely a highly concentrated food. It may in fact improve the effectiveness of the B6.'
Bernard Rimland, Ph.D.
Autism Research Institute
4182 Adams Avenue
San Diego, CA 92116
(Excerpted from: Dimethylglycine (DMG) for Autism)
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Calcium:
Calcium has been used, especially for twitching during sleep.
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Aloe Vera:
Aloe vera in a liquid solution can make food digest better and behavior seems better. You take a few drops 1/2 hour before a meal to prevent leaky gut.
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